反应详情

Pyridine hydrochloride (100 g; 0.87 mol) and 2-methoxy-4-nitro-benzonitrile (17 g; ca 96 mmol) was heated to 200° C. for 2 hours, cooled to room temperature and carefully added H2O and EtOAc. The slurry was stirred until all solid dissolved. The organic layer was isolated, washed twice with H2O, brine then dried, filtered and evaporated to dryness to yield 15 g (95%) pure product

1. dissolutiondissolved
2. customThe organic layer was isolated
3. washwashed twice with H2O, brine
4. customthen dried
5. filtrationfiltered
6. customevaporated to dryness