5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine → HCID 60168622, compound

HRID 1845838Notes

Reaction equation

HRID 1845838 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:25](B(O)O)=[CH:24][CH:23]=1.[CH3:35][PH:36](=[O:38])[CH3:37]>>[Cl:20][C:13]1[C:14]([F:19])=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]([P:36]([CH3:37])([CH3:35])=[O:38])=[CH:24][CH:23]=2)[CH:3]=1)[CH3:11]

Participants

4

Reactant 3

HCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amineHCID 23005424(4-Bromonaphthalen-1-yl)boronic acidHCID 178503022methylphosphonoylmethane

Product 1

HCID 60168622HCID 60168622, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 1-bromo-4-(dihydroxyboryl)naphthalene, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3. ESMS: m/z 503 (M+H)+.

Sources & evidence

ORD record
ord-dc40e2bda8cd4f41b384b8e84b5c630c
Source dataset
uspto-grants-2015_02
Patent number
US08951993B2

Reaction notes

Loading…