5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine → HCID 60168718, compound

HRID 1845849Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]([O:9][CH:10]([C:12]2[C:17]([Cl:18])=[CH:16][CH:15]=[C:14]([F:19])[C:13]=2[Cl:20])[CH3:11])[C:5]([NH2:8])=[N:6][CH:7]=1.Br[C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[C:24]([O:31][C:32]([F:35])([F:34])[F:33])[CH:23]=1.[CH3:36][PH:37](=[O:39])[CH3:38]>>[Cl:20][C:13]1[C:14]([F:19])=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=1[CH:10]([O:9][C:4]1[C:5]([NH2:8])=[N:6][CH:7]=[C:2]([C:25]2[CH:26]=[CH:27][C:22]([P:37]([CH3:38])([CH3:36])=[O:39])=[CH:23][C:24]=2[O:31][C:32]([F:35])([F:34])[F:33])[CH:3]=1)[CH3:11]

Participants

Reactant 3

HCID 211114785-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

HCID 54758858[4-Bromo-2-(trifluoromethoxy)phenyl]boronic acid

HCID 178503022methylphosphonoylmethane

Product 1

HCID 60168718HCID 60168718, compound

Procedure

The title compound was prepared from 5-bromo-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromo-2-trifluoromethoxyphenyl boronic acid, and dimethylphosphine oxide following the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 537 (M+H)+.

Sources & evidence

ORD record: ord-e0cd673911904a329e2f4546bb590f1e
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08951993B2

Reaction notes

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