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HRID1845857

反应详情

EQUATION

反应方程式

HRID 1845857 的结构方程式

REACTANTS

反应物

3
结构：OB(O)c1ccc(Br)cc1F
HCID2773333

4-Bromo-2-fluorobenzeneboronic acid

C6H5BBrFO2

结构：C[C@@H](Oc1cc(Br)cnc1N)c1c(Cl)ccc(F)c1Cl
HCID11689426

(R)-5-Bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

C13H10BrCl2FN2O

结构：C[PH](C)=O
HCID178503022

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](Oc1cc(-c2ccc(P(C)(C)=O)cc2F)cnc1N)c1c(Cl)ccc(F)c1Cl
HCID60168720

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O.CCCCCC
溶剂HCID21585144

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromo-2-fluoro-phenylboronic acid, and dimethylphosphine oxide followed the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 471 (M+H)+; chiral purity 93.12% (column AD-H 4.6*250 mm 5 um; solvent:hexane/isopropanol).