HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzeneboronic acid → (R)-(4-(6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-YL)-3-fluorophenyl)dimethylphosphine oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzeneboronic acid | HCID 2773333 | — |
| Reactant | (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine | HCID 11689426 | — |
| Reactant | methylphosphonoylmethane | HCID 178503022 | — |
| Solvent | Isopropanol hexane | HCID 21585144 | — |
| Product | (R)-(4-(6-Amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-YL)-3-fluorophenyl)dimethylphosphine oxide | HCID 60168720 | — |
Reaction Steps
The title compound was prepared from 5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine, 4-bromo-2-fluoro-phenylboronic acid, and dimethylphosphine oxide followed the same procedures as Example 1 Step 1 and Step 3; ESMS: m/z 471 (M+H)+; chiral purity 93.12% (column AD-H 4.6*250 mm 5 um; solvent:hexane/isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951993B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-8b4bcbdb2336434fab511bf38242c7e5 |
| Source note | uspto-grants-2015_02 |