Hydroxyamine hydrochloride → HCID 137187581, compound

HRID 1845864Notes

Reaction equation

HRID 1845864 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([C:8](=O)[CH3:9])[CH:5]=[CH:4][N:3]=1.Cl.[NH2:12][OH:13].C([O-])(=O)C.[Na+]>C(O)C.O>[NH2:1][C:2]1[N:7]=[C:6]([C:8](=[N:12][OH:13])[CH3:9])[CH:5]=[CH:4][N:3]=1

Participants

6

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 135822701-(2-Aminopyrimidin-4-yl)ethan-1-one

Product 1

HCID 137187581HCID 137187581, compoundYield 96.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a suspension of 1-(2-aminopyrimidin-4-yl)ethanone (3a) (4 g) in ethanol (70 mL) and water (14 mL) was added hydroxylamine hydrochloride (4.05 g) followed by sodium acetate (7.18 g) and the mixture was stirred at room temperature for one hour. After this time the reaction mixture was concentrated in vacuo, water was added and stirred for 15 minutes. The precipitate was collected by filtration and washed with water and dried in vacuo at 40° C. overnight to afford the title product (4.29 g) as a light yellow solid.

Workup

  1. concentrationAfter this time the reaction mixture was concentrated in vacuo, water
  2. additionwas added
  3. stirringstirred for 15 minutes
  4. filtrationThe precipitate was collected by filtration
  5. washwashed with water
  6. customdried in vacuo at 40° C. overnight

Sources & evidence

ORD record
ord-8a5112fcdbb14ab585c10dc44c772036
Source dataset
uspto-grants-2015_02
Patent number
US08952001B2

Reaction notes

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