1-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol → 1-(4-Amino-1,3,5-triazin-2-yl)ethanol

HRID 1845869Notes

Reaction equation

HRID 1845869 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](SC)[N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1>C(O)C.[Ni].O>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1

Participants

5

Reactant 1

HCID 672579331-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol

Product 1

HCID 672560701-(4-Amino-1,3,5-triazin-2-yl)ethanolYield 76.8%

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
85 °C

Procedure

To a solution of 1-(4-amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol (398 mg) in ethanol (20 mL) was added Raney nickel 50% slurry in water (6 mL) and the reaction mixture was heated to 85° C. for 30 minutes then cooled to room temperature, filtered and evaporated to give the title compound (230 mg).

Workup

  1. temperaturethen cooled to room temperature
  2. filtrationfiltered
  3. customevaporated

Sources & evidence

ORD record
ord-4e8caa51a2e446d591c607c667a83b3b
Source dataset
uspto-grants-2015_02
Patent number
US08952001B2

Reaction notes

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