N-(3-Aminopropyl)morpholine → 2,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[3-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

HRID 184589Notes

Reaction equation

HRID 184589 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:34])[c:20]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[c:27]([F:33])[cH:28][cH:29][cH:30][c:31]4[F:32])[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[O:35]1[CH2:36][CH2:37][N:38]([CH2:41][CH2:42][CH2:43][NH2:44])[CH2:39][CH2:40]1>>[c:2]1([NH:44][CH2:43][CH2:42][CH2:41][N:38]2[CH2:37][CH2:36][O:35][CH2:40][CH2:39]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:34])[c:20]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[c:27]([F:33])[cH:28][cH:29][cH:30][c:31]4[F:32])[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 57989776N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 579898982,6-Difluoro-N-{2-fluoro-5-[2-(1-methylethyl)-5-(2-{[3-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Sources & evidence

ORD record
ord-5f38752c8b424770b507beccb35d1258
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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