反应详情

150 mg of 6-(4-tert-butoxycarbonylpiperazin-1-ylsulfonyl)isoquinoline was dissolved in 10 mL of dichloromethane, and 1 mL of 4 M hydrochloric acid-dioxane solution was added dropwise thereto with stirring and then reacted at room temperature for 3 hours. From the reaction solution, the solvent was distilled off, and the obtained residue was dissolved in 0.5 mL of methanol. Then, 5 mL of ethyl acetate was added with vigorous stirring, and the deposited white crystal was collected by filtration and dried to obtain 35 mg of the compound of interest as a white crystal (25%).

1. customreacted at room temperature for 3 hours
2. distillationFrom the reaction solution, the solvent was distilled off
3. dissolutionthe obtained residue was dissolved in 0.5 mL of methanol
4. additionThen, 5 mL of ethyl acetate was added with vigorous stirring
5. filtrationthe deposited white crystal was collected by filtration
6. customdried