1,4-Dioxane hydrochloride → 6-(Piperazin-1-ylsulfonyl)isoquinoline dihydrochloride

Participants

Reaction Steps

150 mg of 6-(4-tert-butoxycarbonylpiperazin-1-ylsulfonyl)isoquinoline was dissolved in 10 mL of dichloromethane, and 1 mL of 4 M hydrochloric acid-dioxane solution was added dropwise thereto with stirring and then reacted at room temperature for 3 hours. From the reaction solution, the solvent was distilled off, and the obtained residue was dissolved in 0.5 mL of methanol. Then, 5 mL of ethyl acetate was added with vigorous stirring, and the deposited white crystal was collected by filtration and dried to obtain 35 mg of the compound of interest as a white crystal (25%).

Provenance & Evidence