2-Fluoro-4-(methylsulphonyl)benzeneboronic acid → 4-[2',6-Difluoro-4'-(methylsulfonyl)biphenyl-3-yl]-7-ethyl-7H-imidazo[4,5-c]pyridazine

HRID 1845982Notes

Reaction equation

HRID 1845982 reaction equation
I[C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[N:17]=[CH:16][N:15]([CH2:18][CH3:19])[C:11]=3[N:12]=[N:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8].[F:20][C:21]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=[CH:23][C:22]=1B(O)O>>[F:20][C:21]1[CH:26]=[C:25]([S:27]([CH3:30])(=[O:29])=[O:28])[CH:24]=[CH:23][C:22]=1[C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([C:9]2[C:10]3[N:17]=[CH:16][N:15]([CH2:18][CH3:19])[C:11]=3[N:12]=[N:13][CH:14]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 447176662-Fluoro-4-(methylsulphonyl)benzeneboronic acidHCID 867232067-ethyl-4-(4-fluoro-3-iodophenyl)-7H-imidazo[4,5-c]pyridazine

Product 1

HCID 867232054-[2',6-Difluoro-4'-(methylsulfonyl)biphenyl-3-yl]-7-ethyl-7H-imidazo[4,5-c]pyridazine

Procedure

Prepared according to the method described above for Example 1 using 4-(3-iodo-4-fluorophenyl)-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 11, 50 mg, 0.16 mmol) and 2-fluoro-4-(methylsulfonyl)phenylboronic acid (68 mg, 0.31 mmol).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-685c7fd29c434d668b9f738e8d36c733
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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