HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(methylsulphonyl)benzeneboronic acid → 4-[2',6-Difluoro-4'-(methylsulfonyl)biphenyl-3-yl]-7-ethyl-7H-imidazo[4,5-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(methylsulphonyl)benzeneboronic acid | HCID 44717666 | — |
| Reactant | 7-ethyl-4-(4-fluoro-3-iodophenyl)-7H-imidazo[4,5-c]pyridazine | HCID 86723206 | — |
| Product | 4-[2',6-Difluoro-4'-(methylsulfonyl)biphenyl-3-yl]-7-ethyl-7H-imidazo[4,5-c]pyridazine | HCID 86723205 | — |
Reaction Steps
Prepared according to the method described above for Example 1 using 4-(3-iodo-4-fluorophenyl)-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 11, 50 mg, 0.16 mmol) and 2-fluoro-4-(methylsulfonyl)phenylboronic acid (68 mg, 0.31 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952008B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-685c7fd29c434d668b9f738e8d36c733 |
| Source note | uspto-grants-2015_02 |