4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine → 4-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine

HRID 1845992Notes

Reaction equation

HRID 1845992 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([CH2:17][CH3:18])(=[O:16])=[O:15])=[CH:10][C:9]=2[O:19][CH3:20])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][CH:3]=1.Cl[C:31]1[C:32]2[N:39]=[CH:38][N:37]([CH2:40][CH3:41])[C:33]=2[N:34]=[N:35][CH:36]=1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([CH2:17][CH3:18])(=[O:15])=[O:16])=[CH:10][C:9]=2[O:19][CH3:20])=[CH:6][C:5]([C:31]2[C:32]3[N:39]=[CH:38][N:37]([CH2:40][CH3:41])[C:33]=3[N:34]=[N:35][CH:36]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 552967654-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazineHCID 867232222-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 867232214-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazineYield 19%

Procedure

Prepared according to the method described for Example 45 using 2-(6-chloro-4′-(ethylsulfonyl)-2′-methoxy-[1,1′-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Preparation 56) and 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8) to afford the title compound as an off white solid in 19% yield, 9.9 mg.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4a4dcca0754b4181a3aec55a006007ed
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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