HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine → 4-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine | HCID 55296765 | — |
| Reactant | 2-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 86723222 | — |
| Product | 4-(6-Chloro-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)-7-ethyl-7H-imidazo[4,5-c]pyridazine | HCID 86723221 | 19% |
Reaction Steps
Prepared according to the method described for Example 45 using 2-(6-chloro-4′-(ethylsulfonyl)-2′-methoxy-[1,1′-biphenyl]-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (Preparation 56) and 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8) to afford the title compound as an off white solid in 19% yield, 9.9 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952008B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-4a4dcca0754b4181a3aec55a006007ed |
| Source note | uspto-grants-2015_02 |