4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine → 5-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-2-carbonitrile

HRID 1845994Notes

Reaction equation

HRID 1845994 reaction equation
[C:1]([C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH2:18][CH3:19])(=[O:17])=[O:16])=[CH:11][C:10]=2[O:20][CH3:21])=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)#[N:2].Cl[C:26]1[C:27]2[N:34]=[CH:33][N:32]([CH2:35][CH3:36])[C:28]=2[N:29]=[N:30][CH:31]=1>>[CH2:35]([N:32]1[C:28]2[N:29]=[N:30][CH:31]=[C:26]([C:6]3[CH:7]=[C:8]([C:9]4[CH:14]=[CH:13][C:12]([S:15]([CH2:18][CH3:19])(=[O:17])=[O:16])=[CH:11][C:10]=4[O:20][CH3:21])[C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[C:27]=2[N:34]=[CH:33]1)[CH3:36]

Participants

3

Reactant 2

HCID 552967654-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazineHCID 86723224(6-Cyano-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)boronic acid

Product 1

HCID 867232235-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-2-carbonitrileYield 10%

Procedure

Prepared according to the method described for Example 45 using (6-cyano-4′-(ethylsulfonyl)-2′-methoxy-[1,1-biphenyl]-3-yl)boronic acid (Preparation 67) and 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8) to afford the title compound as a white solid in 10% yield, 10.1 mg.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-723d84145e0347348d45e0132f01c097
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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