HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine → 5-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chloro-7-ethyl-7H-imidazo(4,5-c)pyridazine | HCID 55296765 | — |
| Reactant | (6-Cyano-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-3-yl)boronic acid | HCID 86723224 | — |
| Product | 5-(7-Ethyl-7H-imidazo[4,5-c]pyridazin-4-yl)-4'-(ethylsulfonyl)-2'-methoxy-[1,1'-biphenyl]-2-carbonitrile | HCID 86723223 | 10% |
Reaction Steps
Prepared according to the method described for Example 45 using (6-cyano-4′-(ethylsulfonyl)-2′-methoxy-[1,1-biphenyl]-3-yl)boronic acid (Preparation 67) and 4-chloro-7-ethyl-7H-imidazo[4,5-c]pyridazine (Preparation 8) to afford the title compound as a white solid in 10% yield, 10.1 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08952008B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-723d84145e0347348d45e0132f01c097 |
| Source note | uspto-grants-2015_02 |