Methyl iodide → 4-Bromo-2-iodo-1-methoxybenzene

HRID 1846035Notes

Reaction equation

HRID 1846035 reaction equation
IC.[Br:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([I:11])[CH:5]=1.[C:12](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:12])=[C:6]([I:11])[CH:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 109245324-Bromo-2-iodophenol

Product 1

HCID 109799044-Bromo-2-iodo-1-methoxybenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Iodomethane (103 μL, 1.65 mmol) was added to a solution of 4-bromo-2-iodophenol (450 mg, 1.51 mmol) and potassium carbonate (271 mg, 1.96 mmol) in acetone (10 mL). The resulting mixture was stirred at room temperature for 16 hours.

Sources & evidence

ORD record
ord-f0f078d4c50d404293eb3ff18ce964e5
Source dataset
uspto-grants-2015_02
Patent number
US08952008B2

Reaction notes

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