反应详情

温度

140 °C

A mixture of 5-chloro-N3-cyclobutylpyridazin-3,4-diamine (Preparation 98, 140 mg, 0.70 mmol) and triethyl orthoformate (4 mL) was heated at 140° C. for 4 hours. After evaporation in vacuo, the crude residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 99:1 to afford the title compound as an off white solid in 54% yield, 80 mg.

1. customAfter evaporation in vacuo
2. customthe crude residue was purified by silica gel column chromatography
3. washeluting with CH2Cl2:MeOH 99:1