HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846059Generated: November 3, 2026
Ethyl orthoformate → 4-Chloro-7-cyclobutyl-7H-imidazo[4,5-c]pyridazine
https://huagongshe.com/reaction/1846059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 5-Chloro-N3-cyclobutylpyridazine-3,4-diamine | HCID 86723280 | — |
| Product | 4-Chloro-7-cyclobutyl-7H-imidazo[4,5-c]pyridazine | HCID 86723281 | 54% |
Reaction Steps
A mixture of 5-chloro-N3-cyclobutylpyridazin-3,4-diamine (Preparation 98, 140 mg, 0.70 mmol) and triethyl orthoformate (4 mL) was heated at 140° C. for 4 hours. After evaporation in vacuo, the crude residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 99:1 to afford the title compound as an off white solid in 54% yield, 80 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08952008B2 |
|---|
| Source dataset | uspto-grants-2015_02 |
|---|
| ORD ID | ord-dc641c0ae8d04a488de35a4efb4d0fcc |
|---|
| Source note | uspto-grants-2015_02 |
|---|
