反应详情

温度

125 °C

A mixture of 3,5-dichloro-4-aminopyridazine (Preparation 4, 2 g, 12.3 mmol) and 70% aqueous propylamine (8 mL) was heated at 125° C. in an autoclave vessel for 5 hours. The reaction mixture was cooled to room temperature and evaporated to dryness. The crude residue was purified by silica gel column chromatography eluting with CH2Cl2:MeOH 98:2 to afford the title compound as a brown solid in 35% yield, 800 mg.

1. temperatureThe reaction mixture was cooled to room temperature
2. customevaporated to dryness
3. customThe crude residue was purified by silica gel column chromatography
4. washeluting with CH2Cl2:MeOH 98:2