HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Sodium Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 58483445 | HCID 58483445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Sodium Chloride | HCID 5234 | — |
| Product | 5-Aminomethyl-2-methyl-benzoic acid hydrochloride (1:1) | HCID 67116183 | — |
Reaction Steps
A mixture of 2-methyl-5-(trifluoromethylcarbonylamino-methyl)benzoic acid (15 mmol; 4.00 g), 1 M NaOH (36 mL) and THF (40 mL) was stirred at rt for 3 h. 4 M aq. HCl solution (5 mL) was added. Concentration under reduced pressure gave the sub-title compound as a mixture with NaCl which was used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-a90cb38f8d88420b81ee9a271a22b8e9 |
| Source note | uspto-grants-2015_02 |