Hydrochloric Acid → Sodium Chloride

HRID 1846071Notes

Reaction equation

HRID 1846071 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12]C(C(F)(F)F)=O)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:20].[ClH:21]>C1COCC1>[ClH:21].[NH2:12][CH2:11][C:8]1[CH:9]=[CH:10][C:2]([CH3:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5].[Na+:20].[Cl-:21]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58483445HCID 58483445, compound

Product 2

HCID 5234Sodium ChlorideHCID 671161835-Aminomethyl-2-methyl-benzoic acid hydrochloride (1:1)

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 2-methyl-5-(trifluoromethylcarbonylamino-methyl)benzoic acid (15 mmol; 4.00 g), 1 M NaOH (36 mL) and THF (40 mL) was stirred at rt for 3 h. 4 M aq. HCl solution (5 mL) was added. Concentration under reduced pressure gave the sub-title compound as a mixture with NaCl which was used without further purification in the next step.

Workup

  1. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-a90cb38f8d88420b81ee9a271a22b8e9
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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