Dichloromethane → HCID 86658665, compound

HRID 1846073Notes

Reaction equation

HRID 1846073 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13]([C:15]2([CH3:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:24])=O.C(Cl)Cl>CN(C=O)C>[CH3:1][C:2]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13]([C:15]2([CH3:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[O:14])=[CH:7][C:3]=1[C:4]([Cl:24])=[O:5]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 58483286HCID 58483286, compound

Product 1

HCID 86658665HCID 86658665, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-methyl-5-[(1-methylcyclohexylcarbonylamino)methyl]benzoic acid (0.250 g, 0.864 mmol), 0.16 mL thionyl chloride, 15 mL DCM and 10 μL DMF were heated at reflux for 2 h and concentrated. The crude acid chloride was used without further purification.

Workup

  1. temperaturewere heated
  2. temperatureat reflux for 2 h
  3. concentrationconcentrated
  4. customThe crude acid chloride was used without further purification

Sources & evidence

ORD record
ord-bd3ba03531e34a23a816624d063a3088
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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