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HRID1846086

反应详情

EQUATION

反应方程式

HRID 1846086 的结构方程式

REACTANTS

反应物

4
结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：CCO.ClCCl
HCID21584144

Dichloromethane ethanol

C3H8Cl2O

结构：CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)O)c1
HCID58483208

未命名化合物

结构：CCOC(=O)c1cc(N)ccc1OCC(F)F
HCID58483394

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1cc(NC(=O)c2cc(CNC(=O)C(C)(C)C)ccc2Cl)ccc1OCC(F)F
HCID87275046

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared analogously to Example 4c from 2 ethyl 5-amino-2-(2,2-difluoroethyl)oxy-benzoate and 2-chloro-5-(tert-butylcarbonylamino)methyl-benzoic acid with TBTU and TEA in THF. Yield: (quantitative). MS [M+H]+=497 (Cl isotope pattern); TLC: Rf=0.35 (silica gel, DCM:EtOH 19:1).