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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846088Generated: November 4, 2026

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 178447315, compound

https://huagongshe.com/reaction/1846088

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
ReactantN-[4-(2,2-difluoroethyl)oxy-3-hydroxycarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamideHCID 86658668—
ReactantHCID 178511531HCID 178511531—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178447315HCID 178447315—

Reaction Steps

Prepared analogously to Example 4c from N-[4-(2,2-difluoroethyl)oxy-3-hydroxycarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide and trans-4-trifluoromethyl-cyclohexylamine with TBTU and TEA in THF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08951999B2
Source datasetuspto-grants-2015_02
ORD IDord-bb76c930348846fe83d7e28010bcb18b
Source noteuspto-grants-2015_02