HRID1846088

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ccc(OCC(F)F)c(C(=O)O)c2)c1

HCID86658668

未命名化合物

HCID178511531

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)C(=O)NCc1ccc(Cl)c(C(=O)Nc2ccc(OCC(F)F)c(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c2)c1

HCID178447315

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared analogously to Example 4c from N-[4-(2,2-difluoroethyl)oxy-3-hydroxycarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide and trans-4-trifluoromethyl-cyclohexylamine with TBTU and TEA in THF.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bb76c930348846fe83d7e28010bcb18b
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08951999B2
来源说明: uspto-grants-2015_02

反应 SMILES

[F:1][CH:2]([F:32])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:28])[C:13]2[CH:18]=[C:17]([CH2:19][NH:20][C:21]([C:23]([CH3:26])([CH3:25])[CH3:24])=[O:22])[CH:16]=[CH:15][C:14]=2[Cl:27])=[CH:7][C:6]=1[C:29]([OH:31])=O.[F:33][C:34]([F:43])([F:42])[C@H:35]1[CH2:40][CH2:39][C@H:38]([NH2:41])[CH2:37][CH2:36]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>C1COCC1>[F:32][CH:2]([F:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:28])[C:13]2[CH:18]=[C:17]([CH2:19][NH:20][C:21]([C:23]([CH3:25])([CH3:24])[CH3:26])=[O:22])[CH:16]=[CH:15][C:14]=2[Cl:27])=[CH:7][C:6]=1[C:29]([NH:41][C@H:38]1[CH2:39][CH2:40][C@H:35]([C:34]([F:33])([F:42])[F:43])[CH2:36][CH2:37]1)=[O:31]