HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Difluoroethan-1-ol → 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Difluoroethan-1-ol | HCID 136187 | — |
| Reactant | 2-Chloro-5-nitropyridine-3-carboxylic acid | HCID 12542664 | — |
| Reactant | Dichloromethane ethanol | HCID 21584144 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid | HCID 86658669 | — |
Reaction Steps
Prepared analogously to Example 5a from 2 chloro-5-nitro nicotinic acid and 2,2-difluoroethanol with KOtBu in THF. Yield: (25%). MS [M−H]−=247; TLC: Rf=0.13 (silica gel, DCM:EtOH 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-452cab8c4fac48359adc1ae88ceaf743 |
| Source note | uspto-grants-2015_02 |