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HRID1846089

反应详情

EQUATION

反应方程式

HRID 1846089 的结构方程式

REACTANTS

反应物

4
结构：OCC(F)F
HCID136187

2,2-Difluoroethanol

C2H4F2O

结构：O=C(O)c1cc([N+](=O)[O-])cnc1Cl
HCID12542664

2-Chloro-5-nitropyridine-3-carboxylic acid

C6H3ClN2O4

结构：CCO.ClCCl
HCID21584144

Dichloromethane ethanol

C3H8Cl2O

结构：CC(C)(C)[O-].[K+]
HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

PRODUCTS

生成物

1
结构：O=C(O)c1cc([N+](=O)[O-])cnc1OCC(F)F
HCID86658669

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared analogously to Example 5a from 2 chloro-5-nitro nicotinic acid and 2,2-difluoroethanol with KOtBu in THF. Yield: (25%). MS [M−H]−=247; TLC: Rf=0.13 (silica gel, DCM:EtOH 9:1).