HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid | HCID 86658669 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(2,2-Difluoroethyl)oxy-5-nitro-nicotinic acid chloride | HCID 58483419 | — |
Reaction Steps
A mixture of 2-(2,2-difluoroethyl)oxy-5-nitro-nicotinic acid (310 mg, 1.25 mmol), 2.0 mL thionyl chloride, 5.0 mL DCM and one drop of DMF was refluxed for 4 h and concentrated i.vac. The corresponding acid chloride was directly used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-1f85543b08c14a02b58e6c42104df552 |
| Source note | uspto-grants-2015_02 |