反应详情

A mixture of 2-(2,2-difluoroethyl)oxy-5-nitro-nicotinic acid (310 mg, 1.25 mmol), 2.0 mL thionyl chloride, 5.0 mL DCM and one drop of DMF was refluxed for 4 h and concentrated i.vac. The corresponding acid chloride was directly used for the next step without further purification.

1. temperaturewas refluxed for 4 h
2. concentrationconcentrated i.vac
3. customThe corresponding acid chloride was directly used for the next step without further purification