HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → N-[4-(4-Methyl-piperidin-1-yl)-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-Chloro-5-[(2,2-dimethylpropanamido)methyl]benzoic acid | HCID 58483208 | — |
| Reactant | N-(4-Bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-amino-benzoic acid amide | HCID 67116511 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-(4-Methyl-piperidin-1-yl)-3-(4-bromophenyl)aminocarbonyl-phenyl]-2-chloro-5-(tert-butylcarbonylamino)methyl-benzamide | HCID 52919849 | — |
Reaction Steps
Prepared analogously to Example 4c from N-(4-bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-amino-benzoic acid amide and 2-chloro-5-(tert-butylcarbonylamino)methyl-benzoic acid with to TBTU and TEA in THF. Purification via chromatography (silica gel, eluent PE:EtOAc 6:4)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-c1c27695828745d2a25ac63a50270562 |
| Source note | uspto-grants-2015_02 |