HRID1846102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

HCID58483208

未命名化合物

结构：CC1CCN(c2ccc(N)cc2C(=O)Nc2ccc(Br)cc2)CC1

HCID67116511

未命名化合物

PRODUCTS

生成物

结构：CC1CCN(c2ccc(NC(=O)c3cc(CNC(=O)C(C)(C)C)ccc3Cl)cc2C(=O)Nc2ccc(Br)cc2)CC1

HCID52919849

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Prepared analogously to Example 4c from N-(4-bromophenyl)-2-(4-methyl-piperidin-1-yl)-5-amino-benzoic acid amide and 2-chloro-5-(tert-butylcarbonylamino)methyl-benzoic acid with to TBTU and TEA in THF. Purification via chromatography (silica gel, eluent PE:EtOAc 6:4)

WORKUP

后处理

customPurification via chromatography (silica gel, eluent PE:EtOAc 6:4)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c1c27695828745d2a25ac63a50270562
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08951999B2
来源说明: uspto-grants-2015_02

反应 SMILES

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:24])[C:10]2[CH:15]=[C:14]([NH2:16])[CH:13]=[CH:12][C:11]=2[N:17]2[CH2:22][CH2:21][CH:20]([CH3:23])[CH2:19][CH2:18]2)=[CH:4][CH:3]=1.[Cl:25][C:26]1[CH:34]=[CH:33][C:32]([CH2:35][NH:36][C:37]([C:39]([CH3:42])([CH3:41])[CH3:40])=[O:38])=[CH:31][C:27]=1[C:28](O)=[O:29].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>C1COCC1>[CH3:23][CH:20]1[CH2:19][CH2:18][N:17]([C:11]2[CH:12]=[CH:13][C:14]([NH:16][C:28](=[O:29])[C:27]3[CH:31]=[C:32]([CH2:35][NH:36][C:37]([C:39]([CH3:40])([CH3:42])[CH3:41])=[O:38])[CH:33]=[CH:34][C:26]=3[Cl:25])=[CH:15][C:10]=2[C:9]([NH:8][C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:24])[CH2:22][CH2:21]1