Hydrochloric Acid → HCID 58483287, compound

HRID 1846110Notes

Reaction equation

HRID 1846110 reaction equation
FC(F)(F)C([NH:5][CH2:6][C:7]1[C:8]([Cl:17])=[C:9]([C:13]([Cl:16])=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])=O.CO.[OH-].[Na+].Cl>O>[NH2:5][CH2:6][C:7]1[C:8]([Cl:17])=[C:9]([C:13]([Cl:16])=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86658673HCID 86658673, compound

Product 1

HCID 58483287HCID 58483287, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Step ii): A mixture of the crude 3-(trifluoromethylcarbonylamino-methyl)-2,6-dichloro-benzoic acid prepared above, 200 mL MeOH, 100 mL H2O and 40 mL 4 M aq. NaOH solution was stirred at rt for 4 h. Then it was acidified with 25 mL 4 M aq. HCl solution, concentrated i. vac. and the residue was diluted with 50 mL MeOH. The precipitate was filtered off and dried to give crude 3-aminomethyl-2,6-dichloro-benzoic acid.

Workup

  1. concentrationconcentrated i
  2. additionand the residue was diluted with 50 mL MeOH
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-e2900f16251c42a0b0d11a83b38e5033
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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