HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivaloyl chloride → 2,6-Difluoro-3-(tert-butylcarbonylamino-methyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | Bis(trimethylsilyl)trifluoroacetamide | HCID 94358 | — |
| Reactant | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| Reactant | 3-(Aminomethyl)-2,6-difluorobenzoic acid | HCID 58483480 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2,6-Difluoro-3-(tert-butylcarbonylamino-methyl)-benzoic acid | HCID 58483339 | — |
Reaction Steps
Prepared analogously to 44b with 3-aminomethyl-2,6-difluorobenzoic acid, Piv-Cl, BSTFA and TEA in THF. Yield: 1.2 g (77%); MS: [m+H]+=272; HPLC: Rt=1.38 min (Method MC-6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-f7cbc469eec047fc85d558065fc6414c |
| Source note | uspto-grants-2015_02 |