HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole → 3-Aminomethyl-2-chloro-6-methylbenzoic acid 3-aminomethyl-2-methyl-6-chlorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| Reactant | 2-Chloro-6-methyl-difluoro-3-(trifluormethylcarbonylamino)methyl-benzoic acid 2-methyl-6-chloro-difluoro-3-(trifluormethylcarbonylamino)methyl-benzoic acid | HCID 131732429 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Aminomethyl-2-chloro-6-methylbenzoic acid 3-aminomethyl-2-methyl-6-chlorobenzoic acid | HCID 86658675 | — |
Reaction Steps
Prepared analogously to 44a with 2-chloro-6-methyl-difluoro-3-(trifluormethylcarbonylamino)methyl-benzoic acid/2-methyl-6-chloro-difluoro-3-(trifluormethylcarbonylamino)methyl-benzoic acid (5.62 g 19 mmol) in 6 M aq. HCl solution. Yield: 4.37 g; (97%; mixture of regioisomers); MS: [M−H]−=198; HPLC: Rt=0.189 min (Method MC-6)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-848499b27b61419996e23dabe45582ff |
| Source note | uspto-grants-2015_02 |