反应详情

Prepared analogously to example 8 with 5-(tert-butoxycarbonylamino)methyl-2-chloro benzoic acid (0.2 g; 0.75 mmol); 1-chloro-N,N,2-trimethylpropenylamine (0.124 mL; 0.9 mmol); 5-amino-2,3-difluorobenzoic acid (0.13 g; 0.75 mmol) and TEA (0.261 mL; 0.88 mmol) in 20 mL THF. Yield: 290 mg (91%); MS: [m+H]+ 425; HPLC: Rt=1.29 min (Method MC-1)