Ethanol → HCID 58483437, compound

HRID 1846118Notes

Reaction equation

HRID 1846118 reaction equation
C([O:3][C:4](=[O:24])[C:5]1[C:10]([Cl:11])=[CH:9][CH:8]=[C:7]([CH2:12][NH:13][C:14]([C:16]([CH3:22])([CH3:21])[C:17]([F:20])([F:19])[F:18])=[O:15])[C:6]=1[F:23])C.CCO>[OH-].[Na+]>[F:23][C:6]1[C:7]([CH2:12][NH:13][C:14]([C:16]([CH3:21])([CH3:22])[C:17]([F:18])([F:19])[F:20])=[O:15])=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]=1[C:4]([OH:24])=[O:3]

Participants

4

Reactant 2

HCID 702EthanolHCID 58483415HCID 58483415, compound

Product 1

HCID 58483437HCID 58483437, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Prepared analogously to example 45f with 2-fluoro-6-chloro-3-[(2,2,2-trifluoro-1,1-dimethylethyl)carbonylamino]methyl-benzoic acid ethylester (1.02 g; 2.76 mmol) in 1 M aq. NaOH with 25 mL EtOH. The solvent was evaporated, diluted with 4 M aq HCl and extracted with DCM, dried with Na2SO4 and concentrated i.vac to obtain the subtitle compound.

Workup

  1. customThe solvent was evaporated
  2. additiondiluted with 4 M aq HCl
  3. extractionextracted with DCM
  4. dry with materialdried with Na2SO4
  5. concentrationconcentrated i.vac

Sources & evidence

ORD record
ord-5af2a31b625d4ec29a0d16d68c5807d8
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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