HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 58483240, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 1-Chloro-N,N-2-trimethylpropenylamine | HCID 640792 | — |
| Reactant | 3,3,3-Trifluoro-2,2-dimethylpropanoic acid | HCID 19867367 | — |
| Reactant | HCID 58483287 | HCID 58483287 | — |
| Reactant | HCID 178433925 | HCID 178433925 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 58483240 | HCID 58483240 | — |
Reaction Steps
Prepared analogously to example 8 with 2,6-dichloro-3-aminomethyl-benzoic acid×HCl (0.257 g; 1 mmol); 1-chloro-N,N,2-trimethylpropenylamine (0.2 mL; 1.51 mmol); 3,3,3-trifluoro-2,2-dimethyl-propionic acid (0.19 g; 1.22 mmol) and pyridine (0.4 mL; 4.96 mmol) in 10 mL MeCN. Yield: 117 mg (33%); MS: [m+H]+ 358 (Cl2 isotope pattern); HPLC: Rt=1.97 min (Method CC-4)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08951999B2 |
| Source dataset | uspto-grants-2015_02 |
| ORD ID | ord-43b04e9f18e44bd184b95b84c2555f53 |
| Source note | uspto-grants-2015_02 |