Hydrochloric Acid → HCID 58483240, compound

HRID 1846120Notes

Reaction equation

HRID 1846120 reaction equation
[Cl:1][C:2]1[C:10]([CH2:11][NH2:12])=[CH:9][CH:8]=[C:7]([Cl:13])[C:3]=1[C:4]([OH:6])=[O:5].Cl.ClC(N(C)C)=C(C)C.[F:23][C:24]([F:32])([F:31])[C:25]([CH3:30])([CH3:29])[C:26](O)=[O:27].N1C=CC=CC=1.ClCl.CC1C2=C(C3C=CC=CC=3)NN(CC3C=CC=CC=3)C(=O)C2=NN=1>CC#N>[Cl:1][C:2]1[C:10]([CH2:11][NH:12][C:26]([C:25]([CH3:30])([CH3:29])[C:24]([F:32])([F:31])[F:23])=[O:27])=[CH:9][CH:8]=[C:7]([Cl:13])[C:3]=1[C:4]([OH:6])=[O:5]

Participants

9

Reactant 7

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 24526ChlorineHCID 6407921-Chloro-N,N-2-trimethylpropenylamineHCID 198673673,3,3-Trifluoro-2,2-dimethylpropanoic acidHCID 58483287HCID 58483287, compoundHCID 178433925HCID 178433925, compound

Product 1

HCID 58483240HCID 58483240, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to example 8 with 2,6-dichloro-3-aminomethyl-benzoic acid×HCl (0.257 g; 1 mmol); 1-chloro-N,N,2-trimethylpropenylamine (0.2 mL; 1.51 mmol); 3,3,3-trifluoro-2,2-dimethyl-propionic acid (0.19 g; 1.22 mmol) and pyridine (0.4 mL; 4.96 mmol) in 10 mL MeCN. Yield: 117 mg (33%); MS: [m+H]+ 358 (Cl2 isotope pattern); HPLC: Rt=1.97 min (Method CC-4)

Sources & evidence

ORD record
ord-43b04e9f18e44bd184b95b84c2555f53
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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