Pyridoxal 5'-phosphate monohydrate → HCID 178482858, compound

HRID 1846121Notes

Reaction equation

HRID 1846121 reaction equation
[CH3:1][N:2]([CH3:25])[C:3]1[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][C:4]=1[C:5]([NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]([F:17])([F:16])[F:15])[CH2:10][CH2:9]1)=[O:6].CC1C(O)=C(C=O)C(COP(O)(O)=O)=CN=1.O>CO.[Pd].[H][H]>[NH2:22][C:19]1[CH:20]=[CH:21][C:3]([N:2]([CH3:25])[CH3:1])=[C:4]([CH:18]=1)[C:5]([NH:7][C@H:8]1[CH2:9][CH2:10][C@H:11]([C:14]([F:16])([F:17])[F:15])[CH2:12][CH2:13]1)=[O:6]

Participants

5

Reactant 2

HCID 38882Pyridoxal 5'-phosphate monohydrateHCID 178482875HCID 178482875, compound

Product 1

HCID 178482858HCID 178482858, compound

Reagents, catalysts & solvents 2

HCID 178506449HCID 178506449, compoundCatalystHCID 887MethanolSolvent

Procedure

Prepared analogously to example 4b with 2-dimethylamino-5-nitro-N-(trans-4-trifluoromethylcyclohexyl)-benzamide (50 mg; 0.14 mmol) with Pd/C/H2 (15 mg/50 psi) in 10 mL MeOH. Yield: quantitative; MS: [m+H]+=330; HPLC: Rt=1.14 min (Method MC-1)

Sources & evidence

ORD record
ord-f97eba87838a405d9ab553c0f59032e4
Source dataset
uspto-grants-2015_02
Patent number
US08951999B2

Reaction notes

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