Hydrochloric Acid → HCID 89964184, compound

HRID 1846222Notes

Reaction equation

HRID 1846222 reaction equation
CC([S@@]([NH:7][C@@:8]1([C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=2)[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[O:11][CH2:10][CH2:9]1)=O)(C)C.[ClH:28].O1CCOCC1>CCO>[ClH:28].[CH:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:26]=[CH:27][C:18]=1[C@:8]1([NH2:7])[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[O:11][CH2:10][CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 89964713HCID 89964713, compound

Product 1

HCID 89964184HCID 89964184, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (S)-2-methyl-N—((S)-4-(naphthalen-2-yl)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-4-yl)propane-2-sulfinamide (45 mg, 0.118 mmol) in EtOH (0.4 mL) was added 4M HCl in 1,4-dioxane (0.059 mL, 0.237 mmol). The mixture was stirred at room temperature for 1 h. The mixture was concentrated and dried in vacuo to give the title compound, which was used in the next step without further purification. MS (ESI, positive ion) m/z: 277.1 (M+H).

Workup

  1. concentrationThe mixture was concentrated
  2. customdried in vacuo

Sources & evidence

ORD record
ord-42ec187cc87b46418943a3757d8962d5
Source dataset
uspto-grants-2015_02
Patent number
US08952009B2

Reaction notes

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