Di-tert-butyl dicarbonate → HCID 89964768, compound

HRID 1846223Notes

Reaction equation

HRID 1846223 reaction equation
Br[C:2]1[C:7]([N:8]([CH2:16][CH2:17][CH:18]=C)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1.BrC1C(NCCC=C)=CC=CN=1.CC([O:36]C(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[O:36]=[C:18]1[C:2]2[C:7](=[CH:6][CH:5]=[CH:4][N:3]=2)[N:8]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 90495Di-tert-butyl dicarbonateHCID 89964350HCID 89964350, compoundHCID 131732430HCID 131732430, compound

Product 1

HCID 89964768HCID 89964768, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl (2-bromopyridin-3-yl)(but-3-en-1-yl)carbamate. To a solution of 2-bromo-N-(but-3-en-1-yl)pyridin-3-amine (1 eq.) and DCM (0.2 M) is added (Boc)2O (1.5 eq.). The solution is stirred at room temperature until judged complete by TLC. The solution is concentrated in vacuo and purified by column chromatography to give the title compound.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-9bbedc54a0a5418694bb09e5e4ee9ab2
Source dataset
uspto-grants-2015_02
Patent number
US08952009B2

Reaction notes

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