Di-tert-butyl dicarbonate → HCID 89964226, compound

HRID 1846230Notes

Reaction equation

HRID 1846230 reaction equation
Br[C:2]1[C:7]([N:8]([CH2:16][CH2:17][CH2:18][CH:19]=C)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1.BrC1C(NCCCC=C)=CC=CN=1.CC([O:38]C(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[O:38]=[C:19]1[CH2:18][CH2:17][CH2:16][N:8]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[C:7]2[CH:6]=[CH:5][CH:4]=[N:3][C:2]1=2

Participants

5

Reactant 3

HCID 90495Di-tert-butyl dicarbonateHCID 89964358HCID 89964358, compoundHCID 131732431HCID 131732431, compound

Product 1

HCID 89964226HCID 89964226, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl (2-bromopyridin-3-yl)(pent-4-en-1-yl)carbamate. To a solution of 2-bromo-N-(pent-4-en-1-yl)pyridin-3-amine (1 eq.) and DCM (0.2 M) is added (Boc)2O (1.5 eq.). The solution is stirred at room temperature until judged complete by TLC. The solution is concentrated in vacuo and purified by column chromatography to give the title compound.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. custompurified by column chromatography

Sources & evidence

ORD record
ord-895620ffbada48708aab7245960c902a
Source dataset
uspto-grants-2015_02
Patent number
US08952009B2

Reaction notes

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