反应详情

温度

20 °C

2-bromo-4-chloro-3-methoxypyridine. Phosphorus oxychloride (10 eq.) and 3-methoxy-2-bromo-4(1H)-pyridone (1 eq.) are stirred at 90° C. for 18 h, concentrated in vacuo, and cooled to 20° C. The residue is treated with ice water and adjusted to pH 12 with 40% NaOH, and the product is extracted into DCM. The residue obtained on evaporation of the combined extracts is distilled at reduced pressure to afford the title compound.

1. concentrationconcentrated in vacuo
2. additionThe residue is treated with ice water
3. extractionthe product is extracted into DCM
4. customThe residue obtained on evaporation of the combined extracts
5. distillationis distilled at reduced pressure