HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1846261Generated: October 30, 2026
Cesium carbonate → 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one
https://huagongshe.com/reaction/1846261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (2-Bromoethoxy)-tert-butyldimethylsilane | HCID 3608067 | — |
| Reactant | 3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)quinazolin-4(3H)-one | HCID 136053081 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one | HCID 58532511 | — |
Reaction Steps
To a solution of 3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)quinazolin-4(3H)-one in anhydrous DMF were added cesium carbonate and (2-bromo-ethoxy)-tert-butyl-dimethyl-silane at room temperature. The reaction mixture was stirred at 80° C. under nitrogen for 15 hours. The reaction mixture was cooled to room temperature and compound 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one (G) was isolated and optionally purified.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08952021B2 |
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| Source dataset | uspto-grants-2015_02 |
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| ORD ID | ord-a142bc208d8b4ad685239750194c66a2 |
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| Source note | uspto-grants-2015_02 |
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