HRID1846261

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID3608067

(2-Bromoethoxy)-tert-butyldimethylsilane

C8H19BrOSi

结构：CCC(C)c1ccc(-n2c(-c3cc(C)c(O)c(C)c3)nc3ccccc3c2=O)cc1

HCID136053081

未命名化合物

PRODUCTS

生成物

结构：CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO[Si](C)(C)C(C)(C)C)c(C)c3)nc3ccccc3c2=O)cc1

HCID58532511

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

To a solution of 3-(4-sec-butylphenyl)-2-(4-hydroxy-3,5-dimethylphenyl)quinazolin-4(3H)-one in anhydrous DMF were added cesium carbonate and (2-bromo-ethoxy)-tert-butyl-dimethyl-silane at room temperature. The reaction mixture was stirred at 80° C. under nitrogen for 15 hours. The reaction mixture was cooled to room temperature and compound 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one (G) was isolated and optionally purified.

WORKUP

后处理

temperatureThe reaction mixture was cooled to room temperature

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a142bc208d8b4ad685239750194c66a2
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08952021B2
来源说明: uspto-grants-2015_02

反应 SMILES

[CH:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=[C:12]2[C:22]2[CH:27]=[C:26]([CH3:28])[C:25]([OH:29])=[C:24]([CH3:30])[CH:23]=2)=[CH:7][CH:6]=1)([CH2:3][CH3:4])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:38][CH2:39][O:40][Si:41]([C:44]([CH3:47])([CH3:46])[CH3:45])([CH3:43])[CH3:42]>CN(C=O)C>[Si:41]([O:40][CH2:39][CH2:38][O:29][C:25]1[C:24]([CH3:30])=[CH:23][C:22]([C:12]2[N:11]([C:8]3[CH:7]=[CH:6][C:5]([CH:1]([CH2:3][CH3:4])[CH3:2])=[CH:10][CH:9]=3)[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)=[CH:27][C:26]=1[CH3:28])([C:44]([CH3:47])([CH3:46])[CH3:45])([CH3:43])[CH3:42]