Tetrabutylammonium Fluoride → 3-(4-sec-butylphenyl)-2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)quinazolin-4(3H)-one

Participants

Reaction Steps

A 1 M solution of tetrabutyl ammonium fluoride in THF was added to a solution of 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one in THF at 0° C. The ice bath was removed, and stirring was continued at room temperature for 2 hours. The solvent was evaporated, and residue was taken in dichloromethane, concentrated and purified as described in Example 1 to give the title compound.

Provenance & Evidence