HRID1846262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO[Si](C)(C)C(C)(C)C)c(C)c3)nc3ccccc3c2=O)cc1

HCID58532511

未命名化合物

PRODUCTS

生成物

结构：CCC(C)c1ccc(-n2c(-c3cc(C)c(OCCO)c(C)c3)nc3ccccc3c2=O)cc1

HCID46700762

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

2 次

PROCEDURE

实验过程

A 1 M solution of tetrabutyl ammonium fluoride in THF was added to a solution of 2-(4-(2-(tert-butyldimethylsilyloxy)ethoxy)-3,5-dimethylphenyl)-3-(4-sec-butylphenyl)quinazolin-4(3H)-one in THF at 0° C. The ice bath was removed, and stirring was continued at room temperature for 2 hours. The solvent was evaporated, and residue was taken in dichloromethane, concentrated and purified as described in Example 1 to give the title compound.

WORKUP

后处理

customThe ice bath was removed
customThe solvent was evaporated
concentrationconcentrated
custompurified

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3a13d8ca0e34a5f93a30fe911706fbf
来源数据集: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08952021B2
来源说明: uspto-grants-2015_02

反应 SMILES

[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Si]([O:26][CH2:27][CH2:28][O:29][C:30]1[C:35]([CH3:36])=[CH:34][C:33]([C:37]2[N:46]([C:47]3[CH:52]=[CH:51][C:50]([CH:53]([CH2:55][CH3:56])[CH3:54])=[CH:49][CH:48]=3)[C:45](=[O:57])[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[N:38]=2)=[CH:32][C:31]=1[CH3:58])(C(C)(C)C)(C)C>C1COCC1>[CH:53]([C:50]1[CH:49]=[CH:48][C:47]([N:46]2[C:45](=[O:57])[C:44]3[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=3)[N:38]=[C:37]2[C:33]2[CH:32]=[C:31]([CH3:58])[C:30]([O:29][CH2:28][CH2:27][OH:26])=[C:35]([CH3:36])[CH:34]=2)=[CH:52][CH:51]=1)([CH2:55][CH3:56])[CH3:54]