反应详情

To a solution of acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester (0.580 g, 1.31 mmol) in methanol (20 mL) was added potassium carbonate (0.55 g, 3.94 mmol). The color changed to yellow. The reaction mixture was stirred at room temperature for 2 hours. Methanol was evaporated. The residue was diluted with water (100 mL), and neutralized to pH 5 with glacial acetic acid. The white precipitate formed was filtered, washed with water and ethyl acetate (20 mL) and dried under vacuum to give 3-(4-sec-butyl-phenyl)-2-(4-hydroxy-3,5-dimethyl-phenyl)-3H-pyrido[4,3-d]pyrimidin-4-one (8) as a white solid. Yield: 0.25 g (48%).

1. customMethanol was evaporated
2. additionThe residue was diluted with water (100 mL)
3. customThe white precipitate formed
4. filtrationwas filtered
5. washwashed with water and ethyl acetate (20 mL)
6. customdried under vacuum