Potassium Carbonate → HCID 136053080, compound

HRID 1846273Notes

Reaction equation

HRID 1846273 reaction equation
[CH:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[C:15]3[CH:18]=[N:19][CH:20]=[CH:21][C:14]=3[N:13]=[C:12]2[C:22]2[CH:27]=[C:26]([CH3:28])[C:25]([O:29]C(=O)C)=[C:24]([CH3:33])[CH:23]=2)=[CH:7][CH:6]=1)([CH2:3][CH3:4])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[C:15]3[CH:18]=[N:19][CH:20]=[CH:21][C:14]=3[N:13]=[C:12]2[C:22]2[CH:27]=[C:26]([CH3:28])[C:25]([OH:29])=[C:24]([CH3:33])[CH:23]=2)=[CH:7][CH:6]=1)([CH2:3][CH3:4])[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58532510HCID 58532510, compound

Product 1

HCID 136053080HCID 136053080, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of acetic acid 4-[3-(4-sec-butyl-phenyl)-4-oxo-3,4-dihydro-pyrido[4,3,d]pyrimidin-2-yl]-2,6-dimethyl-phenyl ester (0.580 g, 1.31 mmol) in methanol (20 mL) was added potassium carbonate (0.55 g, 3.94 mmol). The color changed to yellow. The reaction mixture was stirred at room temperature for 2 hours. Methanol was evaporated. The residue was diluted with water (100 mL), and neutralized to pH 5 with glacial acetic acid. The white precipitate formed was filtered, washed with water and ethyl acetate (20 mL) and dried under vacuum to give 3-(4-sec-butyl-phenyl)-2-(4-hydroxy-3,5-dimethyl-phenyl)-3H-pyrido[4,3-d]pyrimidin-4-one (8) as a white solid. Yield: 0.25 g (48%).

Workup

  1. customMethanol was evaporated
  2. additionThe residue was diluted with water (100 mL)
  3. customThe white precipitate formed
  4. filtrationwas filtered
  5. washwashed with water and ethyl acetate (20 mL)
  6. customdried under vacuum

Sources & evidence

ORD record
ord-4c6e3bac2fdd47c2af41dbb255a7e126
Source dataset
uspto-grants-2015_02
Patent number
US08952021B2

Reaction notes

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