反应详情

A solution of 8-methoxy-1H-benzo[d][1,3]oxazine-2,4-dione (0.50 g, 2.6 mmol) and 4-sec-butylaniline (0.42 g, 2.8 mmol) in DMF (4.0 mL) were stirred at 110° C. under N2 for 24 hours. The mixture was concentrated to dryness then purified by column chromatography on silica gel using ½ EtOAc/hexane as eluent to afford 2-amino-N-(4-sec-butyl-phenyl)-3-methoxy-benzamide as white solid. Yield: 0.533 g (69%).

1. concentrationThe mixture was concentrated to dryness
2. customthen purified by column chromatography on silica gel using ½ EtOAc/hexane as eluent